A triflic acid mediated heteroarylation of phthalaldehydic acid in 1,2-dichloroethane
at reflux temperature leads to the formation of 3-heteroarylphthalides. This method
for the phthalidation of heteroarenes can be utilized for the successful preparation
of mono-, bis- and tris-heteroarylphthalides.
Key words
triflic acid - heteroarylation - 3-heteroarylphthalides - Brønsted acid - Lewis acid